Development of Testing and Testing Models for Huntington's Disease

In his article, Steven Pinker discusses Huntingtons disease (HD) as one of the a few(prenominal) diseases that offer be classified as cistrontic determinism.1 This nub that HD is caused by an autosomally dominant gene; if the trait in head word is inherited, it bequeath be expressed, regardless if it is homozygous or heterozygous dominant. inheritance of this gene leads to uncontrolled movements, loss of mental capabilities and unrestrained disturbance. Currently, in that respect is no word to entirely catch rid of the disease nor are there any methods to dispel or stop the course of HD.2 There has been of import fall out in exploitation treatments for HD. Research surrounding HD often deals with out or keeping(p) types of examination methods and mock ups for the disease. One study used a prelate model to develop scrutiny and treatment in benignants, turn another has identified modernistic prenatal testing for human foetuses.3,4 Both of these studies show the increasing exploration of the genetic science of HD, ultimately to estimate to find helpful symptomatic testing and treatment techniques for this disease. Researchers cipher for treatments in humans by conducting tests on animal models. Some animals, much(prenominal) as prevalent marmoset or rhesus monkey, serve as better models for HD query because they are tight related to humans.

In the research conducted by Hohjoh et al, the researchers identified an ortholog of HD in the common marmoset (Cllithrix jacchus). Through techniques such as reverse transcription, gene cloning and sequencing, the team was able to seques ter and identify the huntingtin (htt), the o! rtholog gene. The discovery of this gene provides an effective non-human primate model of HD.3 The genetic similarities of the common marmoset to humans makes it an ideal model for developing better treatments and diagnostic methods for humans. Another group of scientists have positive a new non-invasive prenatal diagnostic technique for HD. This development was doable because the gene responsible for HD had...If you want to get a honorable essay, target it on our website: BestEssayCheap.com

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