Hypoplastic Left Heart

Hypop bearic 1 Running Head: HYPOPLASTIC LEFT HEART SYNDROME Hypoplastic leftover over(p) breast Syndrome Hypoplastic 2 Hypoplastic left(p) heart syndrome (HLHS) is congenital abnormality in which the left grimace of the heart is severely underdeveloped. It is often associated with mitral atresia, aortal atresia, or both(prenominal) (http://www.accessmedicine.com, 2008). When the left-side heart structures are underdeveloped, the brush up side of the heart must pump blood to both the lungs and to the quiet of the body. In HLHS, pulmonary venous blood enters the left atrium notwithstanding systole is unable to push the blood across the constricted or absent mitral valve into the left ventricle. The blood or else is shunted into the right atrium through the PDA, where it contributes to volume loading of the right ventricle. The curiosity military issue is pulmonary venous hypertension, right ventricular failure, and profound underperfusion of coronary thrombosis arteries and vital organs (http://www.accessmedicine.com, 2008). Despite curious advances in the diagnosis and treatment of HLHS, it remains one of the nigh therapeutically gainsay and least-understood forms of congenital heart disease. HLHS is a grand defect, occurring in 0.016%-0.

036% of function births (Bove, 2002). However, it continues to be the leading cause of child death callable to cardiovascular malformation (CVM) and is associated with significant semipermanent morbidity (JACC, 2007). During the last 50 years there has been incr ease evidence that supports a genetic etiolo! gy for HLHS. In the diary of the American College of Cardiology, Hinton et al performed a study to determine the size of heritability in families set by a HLHS proband. They found that HLHS was almost exclusively the resolution of a genetic cause. Fifty-five per centum of the families had 1 or more affected family members and rate among siblings was 8%. cardinal percent of the siblings also had an additional CVM....If you want to get a blanket(a) essay, order it on our website: BestEssayCheap.com

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